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The compound's ability to restore tissue homeostasis and reverse age-related functional decline in animal models provides direct evidence for the role of senescent cells in aging processes, while its applications in cancer research offer insights into senescence mechanisms in disease progression and administration resistance
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Loliolide (20 μg/mL) significantly increased the size of HDP spheroids in 3D culture and enhanced the expression of growth factors, such as vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), and keratinocyte growth factor (KGF) in HDP spheroids
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