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All four were previously classified under the FDA's Category 2 — flagged for "significant safety concerns" — and are now scheduled for Pharmacy Compounding Advisory Committee (PCAC) review during the July 23–24, 2026 sessions
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One of the ten subjects developed acne one week after vitamin B12 supplementation Consistent with multiple clinical studies previously reporting that vitamin B12 supplementation induces acne in subsets of individuals ( 20–26 ), in the current study, one of the ten healthy subjects, HL414, had multiple erythematous papules and comedones developed on the face one week after vitamin B12 supplementation (Supplementary Materials)
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