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unfortunately, when the supplemental probiotics were taken away, relapsed into depression followed ( 3.1.3.2 Prebiotics Among the long-term supplementation with prebiotics, FOS, GOS, or their combination, promising results appear in demonstrating significant antidepressant and anxiolytic activities in mice ( Akkermansia may increase along with beneficial SCFAs such as acetate and propionate, and the decrease of isobutyrate and stable n-butyrate levels in the gut