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This amino acid change was shown to cause a structural change that impaired binding of SOCS2 resulting in reduced degradation of GHR and extended signaling in response to GH (135)
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Transmission electron microscopy (TEM) imaging of OsO 4 -postfixed HEK293T cells showed that surface LaccID provides excellent contrast at the plasma membrane, with minimal staining of intracellular membranes on the ER, mitochondria and nucleus (Fig
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